Friday, 24 April, 1829

I have now a difficult case to treat, not because the complaint itself is uncommon, but because the individual idiosyncrasy is very peculiar. It is Mrs. Conrad, wife of Jacob Conrad. I am well aware of the difficulty I have now to encounter. My attention must be unremitted, necessary or not, and the time each visit must occupy be considered, and every little circumstance must be explained and remedied. And every symptom of a symptom considered with the utmost gravity. This medicine cannot be used. Doct. Shuman tried that and had to abandon it. Well, you can take some of this. No, that serves me the same way. So I found it would be much the best to say nothing about it, but give and see the effects. And it had no unpleasant effect. You can here see the extent of imagination in producing unpleasant sensations.